I'm interested in optics, laser physics, and biophysics. Much of my research centers on developing novel optical tools and lately I've been building microscopes for noninvasive four-dimensional imaging of biological phenomena at higher resolution and greater depths than previously possible. A biophysicist at heart, these new technologies are aimed at a quantitative understanding of essential biological functions.
Light field-based selective volume illumination microscopy|
We present selective volume illumination microscopy (SVIM), combining the high synchronous volumetric acquisition rates (up to 100 Hz) of light-field microscopy and the high contrast associated with light-sheet microscopy.
Four-dimensional heterogeneity of fluid phase biopsies in cancer|
Clinical Cancer Research 23.7, 1722-1732 (2017)
Nature Reviews Urology Research Highlight
We characteize tumor cells in the fluid phase of blood and bone metastases, and reveal new insights into their biophysical properties and clinical significance.
Super-resolution imaging in live animals|
Nature Communications 5, 4974 (2014)
Nature Method's Methods in Brief /
Biophotonics Research Highlight
We use a new super-resolution fluorescence microscopy method to localize indivdual molecules and track their Brownian diffusion with a precision of 30 nm, directly in live animals.